Brickell Avenue is the name given to the stretch of U.S. Route 1 in Miami, Florida just south of the Miami River.
It is the main road through the Brickell district of Downtown Miami, and is considered to be one of the most prestigious avenue names, as it is associated with big business, wealth and finances.

It is an off-grid plan main north-south thoroughfare through the south part of downtown Miami.

From the Miami River south it continues south-southwest and upon crossing Broadway it curves southwest and continues in that direction until it terminates at Southeast 26th Road/Rickenbacker Causeway, becoming South Federal Highway for a short distance (about 1/4 mile) until it becomes South Dixie Highway.

Brickell (pronounced "BRICK-uhl") is a neighborhood partly within Downtown Miami, Florida. It lies south of the Miami River, extending south to SE 26th Road (the Rickenbacker Causeway), and is mostly mixed financial and residential north of Broadway, and mostly residential south of Broadway.

Brickell Avenue is home to Miami and South Florida's financial district as well as the site of many high-rise luxury condominium and office towers that constantly redefine the Miami skyline. Referred to as the "Manhattan of the South", Brickell is home to the largest concentration of international banks in the United States, mostly along Brickell Avenue, Brickell's main north-south avenue and along Miami Avenue, home to many of Miami's top restaurants, shops and places of entertainment. A few hundred feet east of the northeastern side of Brickell is Brickell Key, an island of upscale, high-rise residential and hotel towers.

The area of Brickell south of Broadway and is mainly low and mid-rise residential buildings west of Brickell Avenue and high-rise residential to the east of Brickell Avenue. This area of Brickell includes the "Millionaires' Row" section of Brickell Avenue, home to many expensive residences, and home to many of Miami's most expensive apartments and condominiums, as well as some iconic Miami skyscrapers, such as the Atlantis Condominium.

Although Brickell Avenue has traditionally been known as a financial district, in recent years, construction of numerous condominium and apartment towers in Brickell, has extended the upscale residential neighborhood feel of lower Brickell into upper Brickell. Recent construction in Brickell has also enlarged the urban core of Brickell from Brickell Avenue west to the Metrorail line, with new office and residential towers, such as Axis at Brickell Village and Mary Brickell Village, built west of Miami Avenue. Today, over 25,000 residents live in Brickell. At the center of Brickell Avenue , is Mary Brickell Village with an assortment of restaurants, boutiques, services that create a gathering area for high-class retail and restaurants. Some the best and most well-known names are leasing space in the project. The project is designed after a French style village and attracts social gathering and entertainment.